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De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints

Molecular evolution has focused on the divergence of molecular functions, yet we know little about how structurally distinct protein folds emerge de novo. We characterized the evolutionary trajectories and selection forces underlying emergence of β-propeller proteins, a globular and symmetric fold g...

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Publicat a:Cell
Autors principals: Smock, Robert G., Yadid, Itamar, Dym, Orly, Clarke, Jane, Tawfik, Dan S.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735018/
https://ncbi.nlm.nih.gov/pubmed/26806127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.024
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