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De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints
Molecular evolution has focused on the divergence of molecular functions, yet we know little about how structurally distinct protein folds emerge de novo. We characterized the evolutionary trajectories and selection forces underlying emergence of β-propeller proteins, a globular and symmetric fold g...
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| Veröffentlicht in: | Cell |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cell Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735018/ https://ncbi.nlm.nih.gov/pubmed/26806127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.024 |
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