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Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

The maintenance of cellular proteins in a biologically active and structurally stable state is a vital endeavor involving multiple cellular pathways. One such pathway is the ubiquitin-proteasome system that represents a major route for protein degradation, and reductions in this pathway usually have...

詳細記述

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書誌詳細
出版年:PLoS Genet
主要な著者: Keith, Scott A., Maddux, Sarah K., Zhong, Yayu, Chinchankar, Meghna N., Ferguson, Annabel A., Ghazi, Arjumand, Fisher, Alfred L.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734690/
https://ncbi.nlm.nih.gov/pubmed/26828939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005823
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