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THE ENDOPLASMIC RETICULUM PROTEIN QUALITY CONTROL ADAPTATION IN A LONG-LIVED C. ELEGANS PROTEASOMAL MUTANT

Protein degradation mechanisms are integral to protein homeostasis. Their reduced efficiency during aging leads to accumulation of misfolded and aggregated proteins which potentiate proteotoxic disorders. Paradoxically, our lab reported that the Caenorhabditis elegans rpn-10(ok1865) proteasome mutan...

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Bibliographische Detailangaben
Veröffentlicht in:Innov Aging
Hauptverfasser: Chinchankar, Meghna N, Rodriguez, Karl, Fisher, Alfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845329/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igz038.373
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