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Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex

The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact b...

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Bibliografische gegevens
Hoofdauteurs: Ghazi, Arjumand, Henis-Korenblit, Sivan, Kenyon, Cynthia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851597/
https://ncbi.nlm.nih.gov/pubmed/17392428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700638104
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