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Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact b...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851597/ https://ncbi.nlm.nih.gov/pubmed/17392428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700638104 |
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