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Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans

How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other...

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Autors principals: Murphy, Coleen T., Lee, Seung-Jae, Kenyon, Cynthia
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141905/
https://ncbi.nlm.nih.gov/pubmed/18025456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709613104
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