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Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2141905/ https://ncbi.nlm.nih.gov/pubmed/18025456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709613104 |
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