Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly

HIV-1 immature particle (virus-like particle [VLP]) assembly is mediated largely by interactions between the capsid (CA) domains of Gag molecules but is facilitated by binding of the nucleocapsid (NC) domain to nucleic acid. We previously investigated the role of SP1, a “spacer” between CA and NC, i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Datta, Siddhartha A. K., Clark, Patrick K., Fan, Lixin, Ma, Buyong, Harvin, Demetria P., Sowder, Raymond C., Nussinov, Ruth, Wang, Yun-Xing, Rein, Alan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Structure and Assembly
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733982/
https://ncbi.nlm.nih.gov/pubmed/26637452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02061-15
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