Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly

HIV-1 immature particle (virus-like particle [VLP]) assembly is mediated largely by interactions between the capsid (CA) domains of Gag molecules but is facilitated by binding of the nucleocapsid (NC) domain to nucleic acid. We previously investigated the role of SP1, a “spacer” between CA and NC, i...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Datta, Siddhartha A. K., Clark, Patrick K., Fan, Lixin, Ma, Buyong, Harvin, Demetria P., Sowder, Raymond C., Nussinov, Ruth, Wang, Yun-Xing, Rein, Alan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Structure and Assembly
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733982/
https://ncbi.nlm.nih.gov/pubmed/26637452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02061-15
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