On the Role of the SP1 Domain in HIV-1 Particle Assembly: a Molecular Switch?

Expression of a retroviral protein, Gag, in mammalian cells is sufficient for assembly of immature virus-like particles (VLPs). VLP assembly is mediated largely by interactions between the capsid (CA) domains of Gag molecules but is facilitated by binding of the nucleocapsid (NC) domain to nucleic a...

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Main Authors: Datta, Siddhartha A. K., Temeselew, Lakew G., Crist, Rachael M., Soheilian, Ferri, Kamata, Anne, Mirro, Jane, Harvin, Demetria, Nagashima, Kunio, Cachau, Raul E., Rein, Alan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Structure and Assembly
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126284/
https://ncbi.nlm.nih.gov/pubmed/21325421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00006-11
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