Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality at embryonic day 10 (E10), with associated cardio...

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Publicado en:Cell Rep
Main Authors: Quétier, Ivan, Marshall, Jacqueline J.T., Spencer-Dene, Bradley, Lachmann, Sylvie, Casamassima, Adele, Franco, Claudio, Escuin, Sarah, Worrall, Joseph T., Baskaran, Priththivika, Rajeeve, Vinothini, Howell, Michael, Copp, Andrew J., Stamp, Gordon, Rosewell, Ian, Cutillas, Pedro, Gerhardt, Holger, Parker, Peter J., Cameron, Angus J.M.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2016
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Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733087/
https://ncbi.nlm.nih.gov/pubmed/26774483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.049
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