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Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality at embryonic day 10 (E10), with associated cardio...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Quétier, Ivan, Marshall, Jacqueline J.T., Spencer-Dene, Bradley, Lachmann, Sylvie, Casamassima, Adele, Franco, Claudio, Escuin, Sarah, Worrall, Joseph T., Baskaran, Priththivika, Rajeeve, Vinothini, Howell, Michael, Copp, Andrew J., Stamp, Gordon, Rosewell, Ian, Cutillas, Pedro, Gerhardt, Holger, Parker, Peter J., Cameron, Angus J.M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2016
Aiheet:
Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733087/
https://ncbi.nlm.nih.gov/pubmed/26774483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.049
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