Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis

The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox buffers present in Mtb, but the contribution of EGT...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Saini, Vikram, Cumming, Bridgette M., Guidry, Loni, Lamprecht, Dirk, Adamson, John H., Reddy, Vineel P., Chinta, Krishna C., Mazorodzo, James, Glasgow, Joel N., Richard-Greenblatt, Melissa, Gomez-Velasco, Anaximandro, Bach, Horacio, Av-Gay, Yossef, Eoh, Hyungjin, Rhee, Kyu, Steyn, Adrie J.C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732560/
https://ncbi.nlm.nih.gov/pubmed/26774486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.056
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