Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis

The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox buffers present in Mtb, but the contribution of EGT...

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Udgivet i:Cell Rep
Main Authors: Saini, Vikram, Cumming, Bridgette M., Guidry, Loni, Lamprecht, Dirk, Adamson, John H., Reddy, Vineel P., Chinta, Krishna C., Mazorodzo, James, Glasgow, Joel N., Richard-Greenblatt, Melissa, Gomez-Velasco, Anaximandro, Bach, Horacio, Av-Gay, Yossef, Eoh, Hyungjin, Rhee, Kyu, Steyn, Adrie J.C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732560/
https://ncbi.nlm.nih.gov/pubmed/26774486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.056
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