Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real time. Mtb infection induced a quiescent energy phenotype in hu...

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Bibliographic Details
Published in:eLife
Main Authors: Cumming, Bridgette M, Addicott, Kelvin W, Adamson, John H, Steyn, Adrie JC
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286123/
https://ncbi.nlm.nih.gov/pubmed/30444490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39169
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