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Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner

In eukaryotes, origin recognition complex (ORC) proteins establish the pre-replicative complex (preRC) at the origins, and this is essential for the initiation of DNA replication. Open chromatin structures regulate the efficiency of preRC formation and replication initiation. However, the molecular...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Giri, Sumanprava, Chakraborty, Arindam, Sathyan, Kizhakke M., Prasanth, Kannanganattu V., Prasanth, Supriya G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732289/
https://ncbi.nlm.nih.gov/pubmed/26644179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.178889
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