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PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape

The six serine/threonine kinases in the p21-activated kinase (PAK) family are important regulators of cell adhesion, motility and survival. PAK6, which is overexpressed in prostate cancer, was recently reported to localize to cell–cell adhesions and to drive epithelial cell colony escape. Here we re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Sci
Hauptverfasser: Morse, Elizabeth M., Sun, Xiaowen, Olberding, Jordan R., Ha, Byung Hak, Boggon, Titus J., Calderwood, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732285/
https://ncbi.nlm.nih.gov/pubmed/26598554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.177493
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