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PAK4 crystal structures suggest unusual kinase conformational movements
In order for protein kinases to exchange nucleotide they must open and close their catalytic cleft. These motions are associated with rotations of the N-lobe, predominantly around the ‘hinge region’. We conducted an analysis of 28 crystal structures of the serine-threonine kinase, p21-activated kina...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5742302/ https://ncbi.nlm.nih.gov/pubmed/28993291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2017.10.004 |
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