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PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape

The six serine/threonine kinases in the p21-activated kinase (PAK) family are important regulators of cell adhesion, motility and survival. PAK6, which is overexpressed in prostate cancer, was recently reported to localize to cell–cell adhesions and to drive epithelial cell colony escape. Here we re...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Morse, Elizabeth M., Sun, Xiaowen, Olberding, Jordan R., Ha, Byung Hak, Boggon, Titus J., Calderwood, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732285/
https://ncbi.nlm.nih.gov/pubmed/26598554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.177493
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