Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway

Screening of new compounds directed against key protein targets must continually keep pace with emerging antibiotic resistances. Although periplasmic enzymes of bacterial cell wall biosynthesis have been among the first drug targets, compounds directed against the membrane-integrated catalysts are h...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Henrich, Erik, Ma, Yi, Engels, Ina, Münch, Daniela, Otten, Christian, Schneider, Tanja, Henrichfreise, Beate, Sahl, Hans-Georg, Dötsch, Volker, Bernhard, Frank
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732233/
https://ncbi.nlm.nih.gov/pubmed/26620564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664292
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