The β(2) clamp in the Mycobacterium tuberculosis DNA polymerase III αβ(2)ε replicase promotes polymerization and reduces exonuclease activity

DNA polymerase III (DNA pol III) is a multi-subunit replication machine responsible for the accurate and rapid replication of bacterial genomes, however, how it functions in Mycobacterium tuberculosis (Mtb) requires further investigation. We have reconstituted the leading-strand replication process...

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Udgivet i:Sci Rep
Main Authors: Gu, Shoujin, Li, Wenjuan, Zhang, Hongtai, Fleming, Joy, Yang, Weiqiang, Wang, Shihua, Wei, Wenjing, Zhou, Jie, Zhu, Guofeng, Deng, Jiaoyu, Hou, Jian, Zhou, Ying, Lin, Shiqiang, Zhang, Xian-En, Bi, Lijun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731781/
https://ncbi.nlm.nih.gov/pubmed/26822057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18418
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