A direct proofreader–clamp interaction stabilizes the Pol III replicase in the polymerization mode

Processive DNA synthesis by the αεθ core of the Escherichia coli Pol III replicase requires it to be bound to the β(2) clamp via a site in the α polymerase subunit. How the ε proofreading exonuclease subunit influences DNA synthesis by α was not previously understood. In this work, bulk assays of DN...

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Auteurs principaux: Jergic, Slobodan, Horan, Nicholas P, Elshenawy, Mohamed M, Mason, Claire E, Urathamakul, Thitima, Ozawa, Kiyoshi, Robinson, Andrew, Goudsmits, Joris M H, Wang, Yao, Pan, Xuefeng, Beck, Jennifer L, van Oijen, Antoine M, Huber, Thomas, Hamdan, Samir M, Dixon, Nicholas E
Format: Artigo
Langue:Inglês
Publié: European Molecular Biology Organization 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642676/
https://ncbi.nlm.nih.gov/pubmed/23435564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.347
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