Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

Accumulation of alpha-synuclein (α-syn) in Lewy bodies and neurites of midbrain dopamine neurons is diagnostic for Parkinson's disease (PD), leading to the proposal that PD is a toxic gain-of-function synucleinopathy. Here we discuss the alternative viewpoint that α-syn displacement from synaps...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Collier, Timothy J., Redmond, D. Eugene, Steece-Collier, Kathy, Lipton, Jack W., Manfredsson, Fredric P.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Psychiatry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731516/
https://ncbi.nlm.nih.gov/pubmed/26858591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00012
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