Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson’s disease. Aggregated α-syn is present in sporadic Parkinson’s disease, both in the central nervous system (CNS) and peripheral nervous system (PNS). The enteric division of the PNS is of particul...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Manfredsson, Fredric P., Luk, Kelvin C., Benskey, Matthew J., Gezer, Aysegul, Garcia, Joanna, Kuhn, Nathan C., Sandoval, Ivette M., Patterson, Joseph R., O’Mara, Alana, Yonkers, Reid, Kordower, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890443/
https://ncbi.nlm.nih.gov/pubmed/29341898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.01.008
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