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The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia
Microglia are resident macrophages of the CNS that are essential for phagocytosis of apoptotic neurons and weak synapses during development. We show that RagA and Lamtor4, two components of the Rag-Ragulator complex, are essential regulators of lysosomes in microglia. In zebrafish lacking RagA funct...
में बचाया:
| में प्रकाशित: | Cell Rep |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731305/ https://ncbi.nlm.nih.gov/pubmed/26774477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.055 |
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