A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

BACKGROUND: Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these compounds hold great potential as therapeutic agents against highly proliferative...

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Detalhes bibliográficos
Publicado no:BMC Struct Biol
Main Authors: Pidugu, Lakshmi Swarna Mukhi, Mbimba, J.C. Emmanuel, Ahmad, Muqeet, Pozharski, Edwin, Sausville, Edward A., Emadi, Ashkan, Toth, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730606/
https://ncbi.nlm.nih.gov/pubmed/26822308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-016-0052-x
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