A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

BACKGROUND: Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these compounds hold great potential as therapeutic agents against highly proliferative...

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Pubblicato in:BMC Struct Biol
Autori principali: Pidugu, Lakshmi Swarna Mukhi, Mbimba, J.C. Emmanuel, Ahmad, Muqeet, Pozharski, Edwin, Sausville, Edward A., Emadi, Ashkan, Toth, Eric A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730606/
https://ncbi.nlm.nih.gov/pubmed/26822308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-016-0052-x
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