Sulfasalazine Treatment Suppresses the Formation of HLA-B27 Heavy Chain Homodimer in Patients with Ankylosing Spondylitis

Human leukocytic antigen-B27 heavy chain (HLA-B27 HC) has the tendency to fold slowly, in turn gradually forming a homodimer, (B27-HC)(2) via a disulfide linkage to activate killer cells and T-helper 17 cells and inducing endoplasmic reticulum (ER) stress to trigger the IL-23/IL-17 axis for pro-infl...

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Publicado no:Int J Mol Sci
Main Authors: Yu, Hui-Chun, Lu, Ming-Chi, Huang, Kuang-Yung, Huang, Hsien-lu, Liu, Su-Qin, Huang, Hsien-Bin, Lai, Ning-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730291/
https://ncbi.nlm.nih.gov/pubmed/26729099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17010046
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