Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells

We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Massart, Renaud, Dymov, Sergiy, Millecamps, Magali, Suderman, Matthew, Gregoire, Stephanie, Koenigs, Kevin, Alvarado, Sebastian, Tajerian, Maral, Stone, Laura S., Szyf, Moshe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730199/
https://ncbi.nlm.nih.gov/pubmed/26817950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19615
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