An epigenetic hypothesis for the genomic memory of pain

Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cyt...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Alvarado, Sebastian, Tajerian, Maral, Suderman, Matthew, Machnes, Ziv, Pierfelice, Stephanie, Millecamps, Magali, Stone, Laura S., Szyf, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371710/
https://ncbi.nlm.nih.gov/pubmed/25852480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00088
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