An epigenetic hypothesis for the genomic memory of pain

Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cyt...

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Pubblicato in:Front Cell Neurosci
Autori principali: Alvarado, Sebastian, Tajerian, Maral, Suderman, Matthew, Machnes, Ziv, Pierfelice, Stephanie, Millecamps, Magali, Stone, Laura S., Szyf, Moshe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371710/
https://ncbi.nlm.nih.gov/pubmed/25852480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00088
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