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Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study

The overall goal of this study was to provide evidence for the clinical validity of nine genetic variants in five genes previously associated with irinotecan neutropenia and pharmacokinetics. Variants associated with absolute neutrophil count (ANC) nadir and/ or irinotecan pharmacokinetics in a disc...

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Publicat a:Pharmacogenomics J
Autors principals: Crona, DJ, Ramirez, J, Qiao, W, de Graan, A-J, Ratain, MJ, van Schaik, RHN, Mathijssen, RHJ, Rosner, GL, Innocenti, F
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729652/
https://ncbi.nlm.nih.gov/pubmed/25869015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.23
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