Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics

PURPOSE: We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients. PATIENTS AND METHODS: Pharmacokinetic, genetic, and clinical data were obtained from 85 advanced canc...

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Detaylı Bibliyografya
Asıl Yazarlar: Innocenti, Federico, Kroetz, Deanna L., Schuetz, Erin, Dolan, M. Eileen, Ramírez, Jacqueline, Relling, Mary, Chen, Peixian, Das, Soma, Rosner, Gary L., Ratain, Mark J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Clinical Oncology 2009
Konular:
Original Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690389/
https://ncbi.nlm.nih.gov/pubmed/19349540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.20.6300
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