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Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study

The overall goal of this study was to provide evidence for the clinical validity of nine genetic variants in five genes previously associated with irinotecan neutropenia and pharmacokinetics. Variants associated with absolute neutrophil count (ANC) nadir and/ or irinotecan pharmacokinetics in a disc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pharmacogenomics J
Hauptverfasser: Crona, DJ, Ramirez, J, Qiao, W, de Graan, A-J, Ratain, MJ, van Schaik, RHN, Mathijssen, RHJ, Rosner, GL, Innocenti, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729652/
https://ncbi.nlm.nih.gov/pubmed/25869015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.23
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