Coagulation factor XIIIa is inactivated by plasmin

Coagulation factor XIIIa (FXIIIa) is a transglutaminase that covalently cross-links fibrin and other proteins to fibrin to stabilize blood clots and reduce blood loss. A clear mechanism to describe the physiological inactivation of FXIIIa has been elusive. Here, we show that plasmin can cleave FXIII...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hur, Woosuk S., Mazinani, Nima, Lu, X. J. David, Britton, Heidi M., Byrnes, James R., Wolberg, Alisa S., Kastrup, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729541/
https://ncbi.nlm.nih.gov/pubmed/26359437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-650713
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