Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking

Factor XIII(a) [FXIII(a)] stabilizes clots and increases resistance to fibrinolysis and mechanical disruption. FXIIIa also mediates red blood cell (RBC) retention in contracting clots and determines venous thrombus size, suggesting FXIII(a) is a potential target for reducing thrombosis. However, the...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Byrnes, James R., Duval, Cédric, Wang, Yiming, Hansen, Caroline E., Ahn, Byungwook, Mooberry, Micah J., Clark, Martha A., Johnsen, Jill M., Lord, Susan T., Lam, Wilbur A., Meijers, Joost C. M., Ni, Heyu, Ariëns, Robert A. S., Wolberg, Alisa S.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2015
Sujets:
Thrombosis and Hemostasis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608241/
https://ncbi.nlm.nih.gov/pubmed/26324704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-652263
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