Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking

Factor XIII(a) [FXIII(a)] stabilizes clots and increases resistance to fibrinolysis and mechanical disruption. FXIIIa also mediates red blood cell (RBC) retention in contracting clots and determines venous thrombus size, suggesting FXIII(a) is a potential target for reducing thrombosis. However, the...

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發表在:Blood
Main Authors: Byrnes, James R., Duval, Cédric, Wang, Yiming, Hansen, Caroline E., Ahn, Byungwook, Mooberry, Micah J., Clark, Martha A., Johnsen, Jill M., Lord, Susan T., Lam, Wilbur A., Meijers, Joost C. M., Ni, Heyu, Ariëns, Robert A. S., Wolberg, Alisa S.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2015
主題:
Thrombosis and Hemostasis
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608241/
https://ncbi.nlm.nih.gov/pubmed/26324704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-652263
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