Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking

Factor XIII(a) [FXIII(a)] stabilizes clots and increases resistance to fibrinolysis and mechanical disruption. FXIIIa also mediates red blood cell (RBC) retention in contracting clots and determines venous thrombus size, suggesting FXIII(a) is a potential target for reducing thrombosis. However, the...

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Опубликовано в: :Blood
Главные авторы: Byrnes, James R., Duval, Cédric, Wang, Yiming, Hansen, Caroline E., Ahn, Byungwook, Mooberry, Micah J., Clark, Martha A., Johnsen, Jill M., Lord, Susan T., Lam, Wilbur A., Meijers, Joost C. M., Ni, Heyu, Ariëns, Robert A. S., Wolberg, Alisa S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2015
Предметы:
Thrombosis and Hemostasis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608241/
https://ncbi.nlm.nih.gov/pubmed/26324704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-652263
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