ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes

Adenosine deaminase acting on RNA 1 (ADAR1) is an essential protein for embryonic liver development. ADAR1 loss is embryonically lethal because of severe liver damage. Although ADAR1 is required in adult livers to prevent liver cell death, as demonstrated by liver-specific conditional knockout (Alb-...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Wang, Guoliang, Wang, Hui, Singh, Sucha, Zhou, Pei, Yang, Shengyong, Wang, Yujuan, Zhu, Zhaowei, Zhang, Jinxiang, Chen, Alex, Billiar, Timothy, Monga, Satdarshan P., Wang, Qingde
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729276/
https://ncbi.nlm.nih.gov/pubmed/26453800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.002
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