ADAR1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

Type I interferons (IFNs) play central roles in innate immunity; however, overproduction of IFN can lead to immunopathology. Here, we demonstrate that adenosine deaminase acting on RNA 1 (ADAR1), an RNA-editing enzyme induced by interferon, is essential for cells to avoid inappropriate sensing of cy...

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Detalhes bibliográficos
Main Authors: Yang, Shengyong, Deng, Peng, Zhu, Zhaowei, Zhu, Jianzhong, Wang, Guoliang, Zhang, Liyong, Chen, Alex F., Wang, Tony, Sarkar, Saumendra N., Billiar, Timothy R., Wang, Qingde
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169998/
https://ncbi.nlm.nih.gov/pubmed/25172485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401136
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