Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain

BACKGROUND: Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset autoimmune disease characterized by inflammatory encephalopathy with an elevated type 1 interferon-stimulated gene (ISG) expression signature in the brain. Mutations in seven different protein-coding genes, all linked...

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Publicado en:J Neuroinflammation
Autores principales: Guo, Xinfeng, Wiley, Clayton A., Steinman, Richard A., Sheng, Yi, Ji, Beihong, Wang, Junmei, Zhang, Liyong, Wang, Tony, Zenatai, Mazen, Billiar, Timothy R., Wang, Qingde
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325854/
https://ncbi.nlm.nih.gov/pubmed/34332594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02217-9
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