Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2

The differentiation factor NEL-like molecule-1 (NELL-1) has been reported as osteoinductive in multiple in vivo preclinical models. Bone morphogenetic protein (BMP)-2 is used clinically for skeletal repair, but in vivo administration can induce abnormal, adipose-filled, poor-quality bone. We demonst...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Shen, Jia, James, Aaron W., Zhang, Xinli, Pang, Shen, Zara, Janette N., Asatrian, Greg, Chiang, Michael, Lee, Min, Khadarian, Kevork, Nguyen, Alan, Lee, Kevin S., Siu, Ronald K., Tetradis, Sotirios, Ting, Kang, Soo, Chia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729267/
https://ncbi.nlm.nih.gov/pubmed/26772960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.10.011
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