Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis

γ-Catenin, an important component of desmosomes, may also participate in Wnt signaling. Herein, we dissect the role of γ-catenin in liver by generating conditional γ-catenin knockout (KO) mice and assessing their phenotype after bile duct ligation (BDL) and diethylnitrosamine-induced chemical carcin...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Zhou, Lili, Pradhan-Sundd, Tirthadipa, Poddar, Minakshi, Singh, Sucha, Kikuchi, Alex, Stolz, Donna B., Shou, Weinian, Li, Zongfang, Nejak-Bowen, Kari N., Monga, Satdarshan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2015
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729235/
https://ncbi.nlm.nih.gov/pubmed/26485505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.019
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