Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients

BACKGROUND: The androgen receptor (AR) is a pivotal drug target for the treatment of prostate cancer, including its lethal castration-resistant (CRPC) form. All current non-steroidal AR antagonists, such as hydroxyflutamide, bicalutamide, and enzalutamide, target the androgen binding site of the rec...

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Vydáno v:Genome Biol
Hlavní autoři: Lallous, Nada, Volik, Stanislav V., Awrey, Shannon, Leblanc, Eric, Tse, Ronnie, Murillo, Josef, Singh, Kriti, Azad, Arun A., Wyatt, Alexander W., LeBihan, Stephane, Chi, Kim N., Gleave, Martin E., Rennie, Paul S., Collins, Colin C., Cherkasov, Artem
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729137/
https://ncbi.nlm.nih.gov/pubmed/26813233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0864-1
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