Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients

BACKGROUND: The androgen receptor (AR) is a pivotal drug target for the treatment of prostate cancer, including its lethal castration-resistant (CRPC) form. All current non-steroidal AR antagonists, such as hydroxyflutamide, bicalutamide, and enzalutamide, target the androgen binding site of the rec...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Lallous, Nada, Volik, Stanislav V., Awrey, Shannon, Leblanc, Eric, Tse, Ronnie, Murillo, Josef, Singh, Kriti, Azad, Arun A., Wyatt, Alexander W., LeBihan, Stephane, Chi, Kim N., Gleave, Martin E., Rennie, Paul S., Collins, Colin C., Cherkasov, Artem
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729137/
https://ncbi.nlm.nih.gov/pubmed/26813233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0864-1
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