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Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47
Thrombospondin-1 regulates inflammation by engaging several cell surface receptors and by modulating activities of other secreted factors. We have uncovered a novel role of thrombospondin-1 in modulating production and activation of the proinflammatory cytokine IL-1β by human and murine macrophages....
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728557/ https://ncbi.nlm.nih.gov/pubmed/26813769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19684 |
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