Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors. We now describe a more potent mechanism by which TSP1 inhibits VEGF receptor-2 (VEGFR2) activation through engaging its receptor CD47. CD47 l...

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Detaylı Bibliyografya
Asıl Yazarlar: Kaur, Sukhbir, Martin-Manso, Gema, Pendrak, Michael L., Garfield, Susan H., Isenberg, Jeff S., Roberts, David D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998110/
https://ncbi.nlm.nih.gov/pubmed/20923780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172304
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