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Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47
Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors. We now describe a more potent mechanism by which TSP1 inhibits VEGF receptor-2 (VEGFR2) activation through engaging its receptor CD47. CD47 l...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998110/ https://ncbi.nlm.nih.gov/pubmed/20923780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172304 |
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