Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.

The macrocyclic peptide cyclotheonamide A (CtA), isolated from the marine sponge Theonella sp., represents an unusual class of serine protease inhibitor. A complex of this inhibitor with human alpha-thrombin, a protease central to the bioregulation of thrombosis and hemostasis, was studied by x-ray...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Maryanoff, B E, Qiu, X, Padmanabhan, K P, Tulinsky, A, Almond, H R, Andrade-Gordon, P, Greco, M N, Kauffman, J A, Nicolaou, K C, Liu, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8367461/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8048
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