Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.

The macrocyclic peptide cyclotheonamide A (CtA), isolated from the marine sponge Theonella sp., represents an unusual class of serine protease inhibitor. A complex of this inhibitor with human alpha-thrombin, a protease central to the bioregulation of thrombosis and hemostasis, was studied by x-ray...

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Detalhes bibliográficos
Main Authors: Maryanoff, B E, Qiu, X, Padmanabhan, K P, Tulinsky, A, Almond, H R, Andrade-Gordon, P, Greco, M N, Kauffman, J A, Nicolaou, K C, Liu, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC47285/
https://ncbi.nlm.nih.gov/pubmed/8367461
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