Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.

Poor bioavailability, rapid degradation, antigenicity, and high cost often limit the use of proteinaceous pharmaceuticals. One goal of structural biochemistry is the reduction of complex molecules to small functional units that are amenable to high-resolution structural analysis and rapid modificati...

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Detalhes bibliográficos
Main Authors: Chen, S, Chrusciel, R A, Nakanishi, H, Raktabutr, A, Johnson, M E, Sato, A, Weiner, D, Hoxie, J, Saragovi, H U, Greene, M I
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC49399/
https://ncbi.nlm.nih.gov/pubmed/1352879
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