Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.

Poor bioavailability, rapid degradation, antigenicity, and high cost often limit the use of proteinaceous pharmaceuticals. One goal of structural biochemistry is the reduction of complex molecules to small functional units that are amenable to high-resolution structural analysis and rapid modificati...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Chen, S, Chrusciel, R A, Nakanishi, H, Raktabutr, A, Johnson, M E, Sato, A, Weiner, D, Hoxie, J, Saragovi, H U, Greene, M I
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1992
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1352879/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.13.5872
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