تحميل...
Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug‐Induced Liver Injury
Tolcapone and entacapone are catechol‐O‐methyltransferase (COMT) inhibitors developed as adjunct therapies for treating Parkinson's disease. While both drugs have been shown to cause mitochondrial dysfunction and inhibition of the bile salt export protein (BSEP), liver injury has only been asso...
محفوظ في:
| الحاوية / القاعدة: | CPT Pharmacometrics Syst Pharmacol |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
John Wiley and Sons Inc.
2016
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728295/ https://ncbi.nlm.nih.gov/pubmed/26844013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12053 |
| الوسوم: |
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