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Integrating mutation and gene expression cross-sectional data to infer cancer progression

BACKGROUND: A major problem in identifying the best therapeutic targets for cancer is the molecular heterogeneity of the disease. Cancer is often caused by an accumulation of mutations which produce irreversible damage to the cell’s control mechanisms of survival and proliferation. Different mutatio...

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Detalhes bibliográficos
Publicado no:BMC Syst Biol
Main Authors: Fleck, Julia L., Pavel, Ana B., Cassandras, Christos G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727329/
https://ncbi.nlm.nih.gov/pubmed/26810975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-016-0255-6
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